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- Panezai, Jeneen, et al.
(author)
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Upregulation of circulating inflammatory biomarkers under the influence of periodontal disease in rheumatoid arthritis patients
- 2020
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In: Cytokine. - : Elsevier. - 1043-4666 .- 1096-0023. ; 131
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Journal article (peer-reviewed)abstract
- OBJECTIVES: Periodontal disease (PD) and rheumatoid arthritis (RA) are chronic immuno-inflammatory conditions with osteolysis being a hallmark feature. The influence of PD on RA's systemic inflammatory status and disease activity remains unclear. The objective of this study was to assess the systemic inflammation and disease activity of RA under the influence of PD.METHODS: In this case-control study, 38 RA patients (19 with PD and 19 without PD) were compared to 38 non-RA patients and 12 healthy controls. Periodontal parameters (bleeding on probing (BOP), probing pocket depth (PPD), PPD Total, PPD Disease and marginal bone loss (MBL) were determined. Serological analyses included quantification of 92 inflammatory biomarkers using a multiplex proximity extension assay, anti-citrullinated protein antibodies (ACPA), rheumatoid factor (IgM-RF) and erythrocyte sedimentation rate (ESR). RA disease activity was determined using Disease Activity Score for 28 joints (DAS28). All RA patients were on medication.RESULTS: IgM-RF was higher in RA patients with PD. PD conditions were more severe in the non-RA group. Inflammatory biomarkers (IL-10RB, IL-18, CSF-1, NT-3, TRAIL, PD-L1, LIF-R, SLAMF1, FGF-19, TRANCE, CST5, STAMPB, SIRT2, TWEAK, CX3CL1, CXCL5, MCP-1) were significantly higher in RA patients with PD than RA without PD. DAS28 associated with twice as many inflammatory biomarkers in RA patients with PD whereas IgM-RF and ACPA associated more frequently with biomarkers in the RA without PD group. IgM-RF correlated inversely with BOP.CONCLUSION: Periodontal disease augments systemic inflammation in RA. A profound influence exists independent of autoimmune status.
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| 3. |
- Svensson, Jakob, 1976-, et al.
(author)
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Who relates to whom and according to which rationale? : Visibility and advocacy in the Ugandan LGBT plus Twittersphere
- 2024
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In: New Media and Society. - : Sage Publications. - 1461-4448 .- 1461-7315.
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Journal article (peer-reviewed)abstract
- An increase in international funding for LGBT+ rights advocacy in Uganda has resulted in not only a mushrooming of organizations but also intra-community competition for visibility, attention, and limited resources. Against this backdrop, we set out to study how organizations relate to each other in the Ugandan LGBT+ Twittersphere. Following an analytical framework around rationalities of mediated participation, we study with whom Ugandan LGBT+ organizations relate through mapping retweets and @mentions emanating from selected Twitter accounts. The resulting network maps reveal a dividing line between more well-funded and internationally connected organizations and lesser established organizations. By supplementing the network analysis with qualitative readings of key accounts and semi-structured interviews, we conclude that access to international funds and negotiating visibility explains the network structures. The article thus reveals interesting Twitter practices, showing LGBT+ organizations use the platform as a means for negotiating and claiming space inside the Ugandan LGBT+ community.
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